Article
An integrated tool to study MHC region: accurate SNV detection and HLA genes typing in human MHC region using targeted high-throughput sequencing.
PloS one - 1 Jan 2013
Cao Hongzhi, Wu Jinghua, Wang Yu, Jiang Hui, Zhang Tao, Liu Xiao, Xu Yinyin, Liang Dequan, Gao Peng, Sun Yepeng, Gifford Benjamin, D'Ascenzo Mark, Liu Xiaomin, Tellier Laurent C A M, Yang Fang, Tong Xin, Chen Dan, Zheng Jing, Li Weiyang, Richmond Todd, Xu Xun, Wang Jun, Li Yingrui
Abstract excerpt
The major histocompatibility complex (MHC) is one of the most variable and gene-dense regions of the human genome. Most studies of the MHC, and associated regions, focus on minor variants and HLA typing, many of which have been demonstrated to be associated with human disease susceptibility and metabolic pathways. However, the detection of variants in the MHC region, and diagnostic HLA typing, still lacks a...
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