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Article

A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long-Read Data.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Apr 2026

Wang Shuai, Wang Xuedong, Wang Mengyao, Zhou Qian, Wang Lusheng, Li Shuai Cheng

Abstract excerpt

Long-read sequencing promises to unravel the complexity of polymorphic immune genes including HLA, KIR, IG, and TCR, yet existing tools fall short in accuracy and scope. Here, we present SpecImmune, the first unified computational framework to simultaneously genotype these genes alongside the intricate CYP family from long-read data. Employing an iterative graph-based haplotype reconstruction algorithm,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to High-Throughput Nucleotide Sequencing

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Share to Polymorphism, Genetic

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Source

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Identifiers

PMID: 41669879
DOI: 10.1002/advs.202521531
PMCID: PMC13088316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long-Read Data.PMID 41669879Read ↗

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