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Benchmarking HLA genotyping from whole genome sequencing across multiple sequencing technologies

2026-02-12

Abstract excerpt

<h4>Background</h4> The hyper⍰polymorphic nature and structural complexity of the human leukocyte antigen (HLA) genomic region present challenges for accurate and scalable typing across diverse sample types. While whole⍰genome sequencing (WGS) offers the opportunity to infer HLA genotypes without targeted enrichment, systematic benchmarks across sequencing platforms, biospecimens and coverage levels remain limite...

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Literature Corpus work: 930b0dbd-279d-5d92-97cb-0b2de9b98b43
DOI: 10.64898/2026.02.10.26345621

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