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MHConstructor: A high-throughput, haplotype-informed solution to the MHC assembly challenge

2024-05-21

Abstract excerpt

The extremely high levels of genetic polymorphism within the human major histocompatibility complex (MHC) limit the usefulness of reference-based alignment methods for sequence assembly. We incorporate a short read de novo assembly algorithm into a workflow for novel application to the MHC. MHConstructor is a containerized pipeline designed for high-throughput, haplotype-informed, reproducible assembly of both wh...

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Literature Corpus work
f721980b-5f7c-5e92-9188-74289a4cb8f1
DOI
10.1101/2024.05.20.595060
Open publication

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MHConstructor: A high-throughput, haplotype-informed solution to the MHC assembly challengeDOI 10.1101/2024.05.20.595060
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