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Article

Development of a high-resolution NGS-based HLA-typing and analysis pipeline.

Nucleic acids research - 23 Jun 2015

Wittig Michael, Anmarkrud Jarl A, Kässens Jan C, Koch Simon, Forster Michael, Ellinghaus Eva, Hov Johannes R, Sauer Sascha, Schimmler Manfred, Ziemann Malte, Görg Siegfried, Jacob Frank, Karlsen Tom H, Franke Andre

Abstract excerpt

The human leukocyte antigen (HLA) complex contains the most polymorphic genes in the human genome. The classical HLA class I and II genes define the specificity of adaptive immune responses. Genetic variation at the HLA genes is associated with susceptibility to autoimmune and infectious diseases and plays a major role in transplantation medicine and immunology. Currently, the HLA genes are characterized using...

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Identifiers

PMID: 25753671
DOI: 10.1093/nar/gkv184
PMCID: PMC4477639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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