Article

Canavanine-based assay for gross chromosomal rearrangements reveals genome instability hotspots and modulating genes in fission yeast

2026-05-16

Abstract excerpt

<h4>Abstract/Summary</h4> Gross chromosomal rearrangements are a hallmark of many diseases and cancers. The study of their biogenesis and the mechanisms underlying their formation is greatly facilitated by the availability of genetic reporter assays in model organisms. We present here a novel GCR assay developed in fission yeast, a highly relevant model for understanding genome instability related to human biolog...

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Literature Corpus work: f86765ec-8eb9-55b0-ae6a-328c4cb37533
DOI: 10.64898/2026.05.15.725498

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