Article
R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements
2019-01-17
Abstract excerpt
Aberrant repair of DNA double-strand breaks can recombine distant pairs of chromosomal breakpoints. Such chromosomal rearrangements are a hallmark of ageing and compromise the structure and function of genomes. Rearrangements are challenging to detect in non-dividing cell populations, because they reflect individually rare, heterogeneous events. The genomic distribution of de novo rearrangements in non-dividing c...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- d68b4744-2697-5aff-a20e-400a7f3615fe
- DOI
- 10.1101/522524