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Article

R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements.

PLoS genetics - 1 Aug 2021

Ellis David A, Reyes-Martín Félix, Rodríguez-López María, Cotobal Cristina, Sun Xi-Ming, Saintain Quentin, Jeffares Daniel C, Marguerat Samuel, Tallada Víctor A, Bähler Jürg

Abstract excerpt

Aberrant repair of DNA double-strand breaks can recombine distant chromosomal breakpoints. Chromosomal rearrangements compromise genome function and are a hallmark of ageing. Rearrangements are challenging to detect in non-dividing cell populations, because they reflect individually rare, heterogeneous events. The genomic distribution of de novo rearrangements in non-dividing cells, and their dynamics during...

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Identifiers

PMID: 34464389
DOI: 10.1371/journal.pgen.1009784
PMCID: PMC8437301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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