Article
Physical and Genetic Assays for the Study of DNA Joint Molecules Metabolism and Multi-invasion-Induced Rearrangements in S. cerevisiae.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Piazza Aurèle, Rajput Pallavi, Heyer Wolf-Dietrich
Abstract excerpt
DNA double-strand breaks (DSBs) are genotoxic lesions that can be repaired in a templated fashion by homologous recombination (HR). HR is a complex pathway that involves the formation of DNA joint molecules (JMs) containing heteroduplex DNA. Various types of JMs are formed throughout the pathway, including displacement loops (D-loops), multi-invasions (MI), and double Holliday junction intermediates....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
