Article
Causes of genome instability.
Annual review of genetics - 1 Jan 2013
Aguilera Andrés, García-Muse Tatiana
Abstract excerpt
Genomes are transmitted faithfully from dividing cells to their offspring. Changes that occur during DNA repair, chromosome duplication, and transmission or via recombination provide a natural source of genetic variation. They occur at low frequency because of the intrinsic variable nature of genomes, which we refer to as genome instability. However, genome instability can be enhanced by exposure to external...
Topics
- Aging
- Animals
- Cell Cycle Checkpoints
- Chromosome Fragile Sites
- DNA Damage
- DNA Repair
- DNA Replication
- DNA, Neoplasm
- Eukaryotic Cells
- Genomic Instability
- Humans
- Mammals