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Article

PhyloWGS: reconstructing subclonal composition and evolution from whole-genome sequencing of tumors.

Genome biology - 13 Feb 2015

Deshwar Amit G, Vembu Shankar, Yung Christina K, Jang Gun Ho, Stein Lincoln, Morris Quaid

Abstract excerpt

Tumors often contain multiple subpopulations of cancerous cells defined by distinct somatic mutations. We describe a new method, PhyloWGS, which can be applied to whole-genome sequencing data from one or more tumor samples to reconstruct complete genotypes of these subpopulations based on variant allele frequencies (VAFs) of point mutations and population frequencies of structural variations. We introduce a...

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Identifiers

PMID: 25786235
DOI: 10.1186/s13059-015-0602-8
PMCID: PMC4359439

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