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Article

ReMixT: clone-specific genomic structure estimation in cancer.

Genome biology - 27 Jul 2017

McPherson Andrew W, Roth Andrew, Ha Gavin, Chauve Cedric, Steif Adi, de Souza Camila P E, Eirew Peter, Bouchard-Côté Alexandre, Aparicio Sam, Sahinalp S Cenk, Shah Sohrab P

Abstract excerpt

Somatic evolution of malignant cells produces tumors composed of multiple clonal populations, distinguished in part by rearrangements and copy number changes affecting chromosomal segments. Whole genome sequencing mixes the signals of sampled populations, diluting the signals of clone-specific aberrations, and complicating estimation of clone-specific genotypes. We introduce ReMixT, a method to unmix tumor and...

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Identifiers

PMID: 28750660
DOI: 10.1186/s13059-017-1267-2
PMCID: PMC5530528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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