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Article

Characterizing Intra-Tumor Heterogeneity From Somatic Mutations Without Copy-Neutral Assumption.

IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000

Ogundijo Oyetunji E, Zhu Kaiyi, Wang Xiaodong, Anastassiou Dimitris

Abstract excerpt

Bulk samples of the same patient are heterogeneous in nature, comprising of different subpopulations (subclones) of cancer cells. Cells in a tumor subclone are characterized by unique mutational genotype profile. Resolving tumor heterogeneity by estimating the genotypes, cellular proportions and the number of subclones present in the tumor can help in understanding cancer progression and treatment. We present a...

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PMID: 32070995
DOI: 10.1109/TCBB.2020.2973635

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