Article

A regulatory interface on RIPK2 is required for XIAP binding and NOD signaling activity

2020-03-12

Abstract excerpt

Signaling via the intracellular pathogen receptors Nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2 requires Receptor Interacting Kinase 2 (RIPK2), an adaptor kinase that can be targeted for the treatment of various inflammatory diseases. However, the molecular mechanisms of how RIPK2 contributes to NOD signaling are not completely understood. We generated FLAG-tagged RIPK2 knock-in mice...

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Literature Corpus work: f7dda6f4-919f-58ab-940d-3bbeb71b12e3
DOI: 10.1101/2020.03.12.988725

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