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Article

XIAP mediates NOD signaling via interaction with RIP2.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Krieg Andreas, Correa Ricardo G, Garrison Jason B, Le Negrate Gaëlle, Welsh Kate, Huang Ziwei, Knoefel Wolfram T, Reed John C

Abstract excerpt

NOD1 and NOD2 are members of the NOD-like receptor (NLR) protein family that are involved in sensing the presence of pathogens and are a component of the innate immune system. Upon activation by specific bacterial peptides derived from peptidoglycans, NODs interact via a CARD-CARD interaction with the receptor-interacting protein kinase RIP2, an inducer of NF-kappaB activation. In this report, we show that NOD...

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Source

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Identifiers

PMID: 19667203
DOI: 10.1073/pnas.0907131106
PMCID: PMC2732880

Genes

XIAP
NOD1
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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