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Article

Resolving the field: a role for Nod2 in T cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2025

Huey Leah M, Rosenzweig Holly L, Napier Ruth J

Abstract excerpt

NOD2 is primarily recognized as a cytosolic bacterial sensor of peptidoglycan, activating a downstream Rip2/NF-κB-mediated antimicrobial signaling pathway and playing a vital role in host defense against bacterial infections. NOD2 also appears to play a critical role in immune homeostasis, as NOD2 variants have been linked to multiple human inflammatory diseases, including common polymorphisms that increase the...

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Arthritis
Crohn Disease
Hereditary Autoinflammatory Diseases
Nod2 Signaling Adaptor Protein
Receptors, Antigen, T-Cell

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Identifiers

PMID: 40824708
DOI: 10.1093/jimmun/vkaf204
PMCID: PMC12726073

Genes

NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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