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Article

Engagement of nucleotide-binding oligomerization domain-containing protein 1 (NOD1) by receptor-interacting protein 2 (RIP2) is insufficient for signal transduction.

The Journal of biological chemistry - 15 Aug 2014

Mayle Sophie, Boyle Joseph P, Sekine Eiki, Zurek Birte, Kufer Thomas A, Monie Tom P

Abstract excerpt

Following activation, the cytoplasmic pattern recognition receptor nucleotide-binding oligomerization domain-containing protein 1 (NOD1) interacts with its adaptor protein receptor-interacting protein 2 (RIP2) to propagate immune signaling and initiate a proinflammatory immune response. This interaction is mediated by the caspase recruitment domain (CARD) of both proteins. Polymorphisms in immune proteins can...

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Identifiers

PMID: 24958724
DOI: 10.1074/jbc.M114.557900
PMCID: PMC4132792

Genes

NOD1

Variants

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