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Article

Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2.

The Journal of biological chemistry - 8 Mar 2013

Ver Heul Aaron M, Fowler C Andrew, Ramaswamy S, Piper Robert C

Abstract excerpt

NOD1 and NOD2 (nucleotide-binding oligomerization domain-containing proteins) are intracellular pattern recognition receptors that activate inflammation and autophagy. These pathways rely on the caspase recruitment domains (CARDs) within the receptors, which serve as protein interaction platforms that coordinately regulate immune signaling. We show that NOD1 CARD binds ubiquitin (Ub), in addition to directly...

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Identifiers

PMID: 23300079
DOI: 10.1074/jbc.M112.413781
PMCID: PMC3591598

Genes

NOD1
NOD2

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