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Article

Insights into the molecular basis of the NOD2 signalling pathway

1 Dec 2014

Abstract excerpt

The cytosolic pattern recognition receptor NOD2 is activated by the peptidoglycan fragment muramyl dipeptide to generate a proinflammatory immune response. Downstream effects include the secretion of cytokines such as interleukin 8, the upregulation of pro-interleukin 1β, the induction of autophagy, the production of antimicrobial peptides and defensins, and contributions to the maintenance of the composition of...

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PMID: 25520185
DOI: 10.1098/rsob.140178

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