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Article

Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.

PloS one - 1 Jan 2017

Pellegrini Erika, Signor Luca, Singh Saurabh, Boeri Erba Elisabetta, Cusack Stephen

Abstract excerpt

Innate immune receptors NOD1 and NOD2 are activated by bacterial peptidoglycans leading to recruitment of adaptor kinase RIP2, which, upon phosphorylation and ubiquitination, becomes a scaffold for downstream effectors. The kinase domain (RIP2K) is a pharmaceutical target for inflammatory diseases caused by aberrant NOD2-RIP2 signalling. Although structures of active RIP2K in complex with inhibitors have been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28545134
DOI: 10.1371/journal.pone.0177161
PMCID: PMC5436651

Genes

NOD2
BRAF
NOD1

Provenance

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