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Article

The Ubiquitin Code of NODs Signaling Pathways in Health and Disease

19 Nov 2019

Abstract excerpt

NOD1 and NOD2 belong to the family of intracellular Nod-like receptors (NLRs) that are involved in the maintenance of tissue homeostasis and host defense against bacteria and some viruses. When sensing such microbes, those NLRs act as hitherto scaffolding proteins for activating multiple downstream inflammatory signaling pathways to promote the production of cytokines and chemokines that are ultimately important...

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PMID: 31803185
DOI: 10.3389/fimmu.2019.02648

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