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Article

Structural and functional insights into CARDs of zebrafish (Danio rerio) NOD1 and NOD2, and their interaction with adaptor protein RIP2.

Molecular bioSystems - 1 Aug 2015

Maharana Jitendra, Dehury Budheswar, Sahoo Jyoti Ranjan, Jena Itishree, Bej Aritra, Panda Debashis, Sahoo Bikash Ranjan, Patra Mahesh Chandra, Pradhan Sukanta Kumar

Abstract excerpt

Nucleotide-binding and oligomerization domain-containing protein 1 (NOD1) and NOD2 are cytosolic pattern-recognition receptors (PRRs) composed of an N-terminal caspase activation and recruitment domain (CARD), a central NACHT domain and C-terminal leucine-rich repeats (LRRs). They play a vital role in innate immune signaling by activating the NF-κB pathway via recognition of peptidoglycans by LRRs, and...

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Identifiers

PMID: 26079944
DOI: 10.1039/c5mb00212e

Genes

NOD1
NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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