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DPP8/9 processing of human AK2 unmasks an IAP binding motif

1 May 2025

Abstract excerpt

Adenylate kinase 2 (AK2) is localized in the intermembrane space of mitochondria, where it ensures efficient adenine nucleotide exchange between cytosol and mitochondria. For mitochondrial import, AK2 relies on the MIA40 disulphide relay system. Its cytosolic stability is subject to regulation through N-terminal processing by the dipeptidyl peptidases DPP8 and DPP9, which sensitize AK2 for proteasomal...

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PMID: 40312560
DOI: 10.1038/s44319-025-00455-z

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