Article
Synaptic exocytosis and nervous system development impaired in Caenorhabditis elegans unc-13 mutants.
Neuroscience - 1 Jan 2001
Maruyama H, Rakow T L, Maruyama I N
Abstract excerpt
C. elegans mutants defective in unc-13 exhibited severe behavioral abnormalities including paralyzed locomotion and slow pharyngeal pumping and irregular defecation cycle. Consistent with the phenotypes, the mutants accumulated abnormally high levels of the neurotransmitter acetylcholine and were resistant to acetylcholinesterase inhibitors. The unc-13 gene was expressed in most, if not all, neurons when analyzed...
Topics
- Acetylcholine
- Acetylcholinesterase
- Animals
- Behavior, Animal
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Calcium Signaling
- Carrier Proteins
- Cholinesterase Inhibitors
- Exocytosis
- Gait Disorders, Neurologic
- Ganglia, Invertebrate
- Gap Junctions
- Gene Expression Regulation, Developmental