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Article

Tomosyn negatively regulates CAPS-dependent peptide release at Caenorhabditis elegans synapses.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Sept 2007

Gracheva Elena O, Burdina Anna O, Touroutine Denis, Berthelot-Grosjean Martine, Parekh Hetal, Richmond Janet E

Abstract excerpt

The syntaxin-interacting protein tomosyn is thought to be a key regulator of exocytosis, although its precise mechanism of action has yet to be elucidated. Here we examined the role of tomosyn in peptide secretion in Caenorhabditis elegans tomosyn (tom-1) mutants. Ultrastructural analysis of tom-1 mutants revealed a 50% reduction in presynaptic dense-core vesicles (DCVs) corresponding to enhanced neuropeptide...

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Source

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Identifiers

PMID: 17881523
DOI: 10.1523/JNEUROSCI.2339-07.2007
PMCID: PMC3874420

Genes

CAPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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