Article
Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.
The Journal of biological chemistry - 24 Jan 1997
Betz A, Okamoto M, Benseler F, Brose N
Abstract excerpt
unc-13 mutants in Caenorhabditis elegans are characterized by a severe deficit in neurotransmitter release. Their phenotype is similar to that of the C. elegans unc-18 mutation, which is thought to affect synaptic vesicle docking to the active zone. This suggests a crucial role for the unc-13 gen...
Topics
- Animals
- Binding Sites
- Brain Chemistry
- Caenorhabditis elegans Proteins
- Carrier Proteins
- Helminth Proteins
- Membrane Proteins
- Nerve Tissue Proteins
- Peptide Mapping
- Phenotype
- Qa-SNARE Proteins
- R-SNARE Proteins
- Rats
- Structure-Activity Relationship
- Substrate Specificity
- Synaptosomal-Associated Protein 25