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Article

Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.

The Journal of biological chemistry - 24 Jan 1997

Betz A, Okamoto M, Benseler F, Brose N

Abstract excerpt

unc-13 mutants in Caenorhabditis elegans are characterized by a severe deficit in neurotransmitter release. Their phenotype is similar to that of the C. elegans unc-18 mutation, which is thought to affect synaptic vesicle docking to the active zone. This suggests a crucial role for the unc-13 gene product in the mediation or regulation of synaptic vesicle exocytosis. Munc13-1 is one of three closely related rat...

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Source

Identifiers

PMID: 8999968
DOI: 10.1074/jbc.272.4.2520

Genes

SNAP25

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.PMID 8999968Read ↗

UNC-13 interaction with syntaxin is required for synaptic transmission.Semantic proximity Read ↗

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming.Semantic proximity Read ↗

Drosophila UNC-13 is essential for synaptic transmission.Semantic proximity Read ↗

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.Semantic proximity Read ↗

Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13.Semantic proximity Read ↗

Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans.Semantic proximity Read ↗

A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming.Semantic proximity Read ↗

UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin.Semantic proximity Read ↗

Open syntaxin overcomes synaptic transmission defects in diverse <i>C. elegans</i> exocytosis mutantsSemantic proximity Read ↗

Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.Semantic proximity Read ↗

The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1.Semantic proximity Read ↗

Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans.Semantic proximity Read ↗

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