Article

Predictable clonal hierarchies from restricted progenitors provide a framework for cell type-specific therapies in glioblastoma

2026-02-23

Abstract excerpt

Extensive molecular profiling has revealed profound heterogeneity in glioblastoma (GBM), yet how cellular lineages organize over time to govern tumor propagation and therapeutic response remains poorly understood. Existing single-cell approaches define transcriptional states but provide limited insight into how clonal dynamics shape functional tumor behavior. Here, we integrate high-complexity combinatorial DNA ba...

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Literature Corpus work: f785dea4-1e91-5a86-b764-d4f4cf6de2ee
DOI: 10.64898/2026.02.21.707071

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