Article

A single-cell atlas of human glioblastoma reveals a single axis of phenotype in tumor-propagating cells

2018-07-26

Abstract excerpt

Tumor-propagating glioblastoma (GBM) stem-like cells (GSCs) of the proneural and mesenchymal molecular subtypes have been described. However, it is unknown if these two GSC populations are sufficient to generate the spectrum of cellular heterogeneity observed in GBM. The lineage relationships and niche interactions of GSCs have not been fully elucidated. We perform single-cell RNA-sequencing (scRNA-seq) and matche...

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Literature Corpus work: 604496a9-3396-5272-b3c5-3a75cd944447
DOI: 10.1101/377606

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