Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.

doi:10.1038/nature23666

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Article

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.

Nature - 14 Sept 2017

Lan Xiaoyang, Jörg David J, Cavalli Florence M G, Richards Laura M, Nguyen Long V, Vanner Robert J, Guilhamon Paul, Lee Lilian, Kushida Michelle M, Pellacani Davide, Park Nicole I, Coutinho Fiona J, Whetstone Heather, Selvadurai Hayden J, Che Clare, Luu Betty, Carles Annaick, Moksa Michelle, Rastegar Naghmeh, Head Renee, Dolma Sonam, Prinos Panagiotis, Cusimano Michael D, Das Sunit, Bernstein Mark, Arrowsmith Cheryl H, Mungall Andrew J, Moore Richard A, Ma Yussanne, Gallo Marco, Lupien Mathieu, Pugh Trevor J, Taylor Michael D, Hirst Martin, Eaves Connie J, Simons Benjamin D, Dirks Peter B

Abstract excerpt

Human glioblastomas harbour a subpopulation of glioblastoma stem cells that drive tumorigenesis. However, the origin of intratumoural functional heterogeneity between glioblastoma cells remains poorly understood. Here we study the clonal evolution of barcoded glioblastoma cells in an unbiased way following serial xenotransplantation to define their individual fate behaviours. Independent of an evolving mutational...

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Identifiers

PMID: 28854171
DOI: 10.1038/nature23666
PMCID: PMC5608080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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