Article

A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

2025-05-14

Abstract excerpt

Cancer cells display highly heterogeneous and plastic states in glioblastoma, an incurable brain tumour. However, how these malignant states arise and whether they follow defined cellular trajectories across tumours is poorly understood. Here, we generated a deep single cell and spatial multi-omic atlas of human glioblastoma that pairs transcriptomic, epigenomic and genomic profiling of 12 tumours across multiple...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e6524858-495f-5511-bd09-60ea691a4bd3
DOI: 10.1101/2025.05.13.653495

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneityDOI 10.1101/2025.05.13.653495Read

Spatially Integrated Multi-Omics reveals the Multicellular Landscape of Progenitor-Driven Glioblastoma ProgressionSemantic proximity Read

Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant gliomaSemantic proximity Read

Tissue-reactive zonation of mesenchymal-like phenotypes in human glioblastoma.Semantic proximity Read

Charting the single-cell and spatial landscape of IDH-wild-type glioblastoma with GBmapSemantic proximity Read

The Hallmarks of Glioblastoma: Heterogeneity, Intercellular Crosstalk and Molecular Signature of Invasiveness and ProgressionSemantic proximity Read

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamicsSemantic proximity Read

Microenvironment-Driven Dynamic Chromatin Changes in Glioblastoma Recapitulate Early Neural Development at Single-Cell ResolutionSemantic proximity Read

A single-cell atlas of human glioblastoma reveals a single axis of phenotype in tumor-propagating cellsSemantic proximity Read

Single-cell RNA-seq reveals that glioblastoma recapitulates normal brain developmentSemantic proximity Read

Genetic evolution and cellular interactions within the tumour microenvironment determine glioblastoma progressionSemantic proximity Read

Glioblastoma Heterogeneity and Cancer Cell PlasticitySemantic proximity Read

Harmonized single-cell landscape, intercellular crosstalk and tumor architecture of glioblastomaSemantic proximity Read