Article

Mapping the Stemness Landscape of Glioblastoma to Drive Heterogeneity and Drug Resistance: Bridging Pathological Omics with Prognostic Outcomes

2026-08-20

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : Glioblastoma (GBM) exhibits profound cellular heterogeneity and therapeutic resistance, largely driven by glioblastoma stem cells (GSC), yet their spatial dynamics and regulatory mechanisms remain incompletely understood. <bold>Methods</bold> : We integrated large-scale single-cell and spatial transcriptomic datasets encompassing over 338,000 cells, combin...

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Literature Corpus work: 9c78d378-6db4-516e-899f-5e40ec69f217
DOI: 10.21203/rs.3.rs-9815299/v1

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