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Germline hypomethylation shapes dynamic CpG reservoirs in ape genomes

2026-06-19

Abstract excerpt

Telomere-to-telomere (T2T) genome assemblies resolve DNA methylation of complete ape genomes, including repetitive and satellite-rich compartments that were largely inaccessible in previous primate reference genomes. Here, integrating complete ape genome assemblies with long- and short-read germline and somatic DNA methylomes, we demonstrate dual roles of germline DNA methylation. While solidifying germline DNA me...

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Literature Corpus work
d2398dbe-ca3c-57f3-885f-c55614eac759
DOI
10.64898/2026.06.15.732472
Open publication

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Germline hypomethylation shapes dynamic CpG reservoirs in ape genomesDOI 10.64898/2026.06.15.732472
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