Article
Charting a dynamic DNA methylation landscape of the human genome.
Nature - 22 Aug 2013
Ziller Michael J, Gu Hongcang, Müller Fabian, Donaghey Julie, Tsai Linus T-Y, Kohlbacher Oliver, De Jager Philip L, Rosen Evan D, Bennett David A, Bernstein Bradley E, Gnirke Andreas, Meissner Alexander
Abstract excerpt
DNA methylation is a defining feature of mammalian cellular identity and is essential for normal development. Most cell types, except germ cells and pre-implantation embryos, display relatively stable DNA methylation patterns, with 70-80% of all CpGs being methylated. Despite recent advances, we still have a limited understanding of when, where and how many CpGs participate in genomic regulation. Here we report...
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