Article

Prodromal dysfunction of α5GABA-A receptor modulated hippocampal ripples in Alzheimer’s disease

2021-05-11

Abstract excerpt

Decades of research attempting to slow the onset of Alzheimer’s disease (AD) indicates that a better understanding of memory will be key to the discovery of effective therapeutic approaches. Here, we ask whether prodromal neural network dysfunction might occur in the hippocampal trisynaptic circuit by using α5IA as a selective negative modulator of extrasynaptic α5GABA-A receptors in TgF344-AD transgenic rats, a m...

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Literature Corpus work: f75ab1df-82bf-557c-a250-8c074c87f695
DOI: 10.1101/2021.05.10.443512

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