Article

Circuit-specific selective vulnerability in the DMN persists in the face of widespread amyloid burden

2022-11-14

Abstract excerpt

<h4>ABSTRACT</h4> The relationship between brainwide functional decline and accumulation of pathological protein aggregates in Alzheimer’s disease (AD) is complex and not well understood. A set of highly interconnected cortical regions known as the default mode network (DMN) exhibits selective vulnerability to both functional decline and amyloid beta (A β ) plaques in early AD. One possibility is that early A β...

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Literature Corpus work: a469bcaa-15a9-58d5-b7b7-433a14cdae80
DOI: 10.1101/2022.11.14.516510

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