Article

Acute exposure of mouse and human hippocampal slices to tau oligomers reversibly impairs sharp-wave ripples

2026-04-07

Abstract excerpt

Sharp-wave ripple (SWR) oscillations are crucial for memory consolidation and deteriorate in Alzheimer’s disease (AD). Tau oligomers are suggested to lead to synaptic and neuronal degeneration in AD, but their effects on SWRs are unknown. To study this, we prepared mouse and human hippocampal slices and bath-applied tau oligomer preparations after spontaneous SWR generation. In human slices, acute exposure to tau...

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Literature Corpus work: c3ec13ee-fcd5-550c-a99c-4f2573f7a487
DOI: 10.64898/2026.04.05.716545

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