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Article

Behavioral Phenotype in the TgF344-AD Rat Model of Alzheimer’s Disease

16 Jun 2020

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disease resulting in cognitive decline. A unique rat model, TgF344-AD, recapitulates pathological hallmarks of AD. We used a longitudinal design to address the timing of expression of behavioral phenotypes in male and female TgF344-AD rats. In both sexes, we confirmed an age-dependent buildup of amyloid-β. In the open field, female, but not male,...

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PMID: 32612506
DOI: 10.3389/fnins.2020.00601

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