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GABA<sub>A</sub>receptor availability in clinical high-risk and first-episode psychosis: a [<sup>11</sup>C]Ro15-4513 positron emission tomography study

2025-02-28

Abstract excerpt

Disrupted gamma-aminobutyric acid (GABA) neurotransmission may contribute to the pathophysiology of schizophrenia. Reductions in hippocampal GABAergic neurons have been found in schizophrenia, and increased hippocampal perfusion has been described in schizophrenia and in people at clinical high-risk for psychosis (CHRp). We have also found decreases in hippocampal GABA A receptors containing the α5 subunit (GABA A...

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Literature Corpus work
4bbe3ea1-88e6-5e96-9d5f-b9d61b91e76c
DOI
10.1101/2025.02.27.25322861
Open publication

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GABA<sub>A</sub>receptor availability in clinical high-risk and first-episode psychosis: a [<sup>11</sup>C]Ro15-4513 positron emission tomography studyDOI 10.1101/2025.02.27.25322861
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