Article

The pathological hallmarks of Alzheimer’s disease derive from compensatory responses to NMDA receptor insufficiency

2018-09-17

Abstract excerpt

Alzheimer’s disease is characterized by intracellular aggregates of hyperphosphorylated tau protein and extracellular plaques of amyloid β peptide, a product of APP processing. The origin of these pathological hallmarks has remained elusive. Here, we have tested the idea that both alterations, at the onset of the disease, may constitute compensatory responses to the same causative and initial trigger, namely NMDA...

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Literature Corpus work: 62c68445-b4da-5b98-8861-722694bbd392
DOI: 10.1101/418566

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