Article
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps.
Cell - 22 Dec 2021
Chen Bob, Scurrah Cherie' R, McKinley Eliot T, Simmons Alan J, Ramirez-Solano Marisol A, Zhu Xiangzhu, Markham Nicholas O, Heiser Cody N, Vega Paige N, Rolong Andrea, Kim Hyeyon, Sheng Quanhu, Drewes Julia L, Zhou Yuan, Southard-Smith Austin N, Xu Yanwen, Ro James, Jones Angela L, Revetta Frank, Berry Lynne D, Niitsu Hiroaki, Islam Mirazul, Pelka Karin, Hofree Matan, Chen Jonathan H, Sarkizova Siranush, Ng Kimmie, Giannakis Marios, Boland Genevieve M, Aguirre Andrew J, Anderson Ana C, Rozenblatt-Rosen Orit, Regev Aviv, Hacohen Nir, Kawasaki Kenta, Sato Toshiro, Goettel Jeremy A, Grady William M, Zheng Wei, Washington M Kay, Cai Qiuyin, Sears Cynthia L, Goldenring James R, Franklin Jeffrey L, Su Timothy, Huh Won Jae, Vandekar Simon, Roland Joseph T, Liu Qi, Coffey Robert J, Shrubsole Martha J, Lau Ken S
Abstract excerpt
Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights when analyzed at high resolution. We present a single-cell transcriptomic and imaging atlas of the two most common human colorectal polyps, conventional adenomas and serrated polyps, and their resulting CRC counterparts. Integrative...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.