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Article

Lynch syndrome - cancer pathways, heterogeneity and immune escape.

The Journal of pathology - 1 Oct 2018

Seth Sidhant, Ager Ann, Arends Mark J, Frayling Ian M

Abstract excerpt

Recent work has provided evidence for genetic and molecular heterogeneity in colorectal cancers (CRCs) arising in patients with Lynch syndrome (LS), dividing these into two groups: G1 and G2. In terms of mutation and gene expression profile, G1 CRCs bear resemblance to sporadic CRCs with microsatellite instability (MSI), whereas G2 CRCs are more similar to microsatellite-stable CRCs. Here we review the current...

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Identifiers

PMID: 30027543
DOI: 10.1002/path.5139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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