Single-cell technology reveals the crosstalk between tumor cells and immune cells: driving immune signal transduction and inflammation-mediated cardiac dysfunction in the tumor microenvironment of colorectal cancer

Abstract excerpt

Background Colorectal cancer (CRC) is a heterogeneous illness influenced by intricate tumor-immune interactions and characterized by a dismal prognosis. Macrophage-mediated immunological signaling facilitates tumor proliferation and may associate inflammation in the tumor microenvironment (TME) of CRC with negative outcomes. Notwithstanding therapeutic advancements, resistance to treatment remains a significant...

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