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Article

A Functionally Constrained Immune Ecosystem in Microsatellite-stable Colorectal Cancer Resolved by Single-cell and Exome Profiling.

Cancer genomics & proteomics - 1 Jan 2026

Liu Wenxu, Zheng Yipan, Wang Hao, Qi Feng, Zhao Xiulan, Ma Zhenyi, Liu Zhe

Abstract excerpt

BACKGROUND/AIM: Microsatellite-stable (MSS) colorectal cancer (CRC) generally responds poorly to immune checkpoint blockade, but some MSS tumors are T-cell rich. We examined whether such infiltration reflected effective immunity or functional immune constraint. CASE REPORT: A 77-year-old woman underwent resection of a mismatch repair-proficient (pMMR), MSS, low-mutational-burden CRC with a synchronous adenoma....

Read the complete abstract on PubMed

Topics

Humans
Female
Aged
Colorectal Neoplasms
Exome Sequencing
Single-Cell Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Microsatellite Instability

Microsatellite Repeats

T-Lymphocytes, Regulatory

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42674816
DOI: 10.21873/cgp.20615
PMCID: PMC13531133

Genes

APC
CD44
CD74
FN1
KRAS
MIF
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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