Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic Landscape of Lynch Syndrome Colorectal Neoplasia Identifies Shared Mutated Neoantigens for Immunoprevention.

Gastroenterology - 1 May 2024

Bolivar Ana M, Duzagac Fahriye, Deng Nan, Reyes-Uribe Laura, Chang Kyle, Wu Wenhui, Bowen Charles M, Taggart Melissa W, Thirumurthi Selvi, Lynch Patrick M, You Y Nancy, Rodriguez-Pascual Jesus, Lipkin Steven M, Kopetz Scott, Scheet Paul, Lizee Gregory A, Reuben Alexandre, Sinha Krishna M, Vilar Eduardo

Abstract excerpt

BACKGROUND & AIMS: Lynch syndrome (LS) carriers develop mismatch repair-deficient neoplasia with high neoantigen (neoAg) rates. No detailed information on targetable neoAgs from LS precancers exists, which is crucial for vaccine development and immune-interception strategies. We report a focused somatic mutation and frameshift-neoAg landscape of microsatellite loci from colorectal polyps without malignant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to Cancer Vaccines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to DNA Mismatch Repair

Share to Exome Sequencing

Share to Frameshift Mutation

Share to Microsatellite Instability

Source

Open in PubMed Open full text

Identifiers

PMID: 38244726
DOI: 10.1053/j.gastro.2024.01.016
PMCID: PMC11034773

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic Landscape of Lynch Syndrome Colorectal Neoplasia Identifies Shared Mutated Neoantigens for Immunoprevention.PMID 38244726Read ↗

Discovery and validation of frameshift-derived neopeptides in Lynch syndrome: paving the way for novel cancer prevention strategiesSemantic proximity Read ↗

Evolving neoantigen profiles in colorectal cancers with DNA repair defectsSemantic proximity Read ↗

Evolving neoantigen profiles in colorectal cancers with DNA repair defectsSemantic proximity Read ↗

Lynch syndrome cancer vaccines: A roadmap for the development of precision immunoprevention strategiesSemantic proximity Read ↗

Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome.Semantic proximity Read ↗

Vaccines for immunoprevention of DNA mismatch repair deficient cancersSemantic proximity Read ↗

Immunogenomic Biomarkers for Early Cancer Detection in Lynch SyndromeSemantic proximity Read ↗

Whole-Exome Sequencing to Screen Personal Neoantigens With High Immunogenicity in Patients With Microsatellite Stability (MSS)-Advanced Colorectal Cancer.Semantic proximity Read ↗

Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4.Semantic proximity Read ↗

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps.Semantic proximity Read ↗

Recurrent Neoantigens in Colorectal Cancer as Potential Immunotherapy TargetsSemantic proximity Read ↗

Lynch Syndrome and MSI-H Cancers: From Mechanisms to “Off-The-Shelf” Cancer VaccinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.