Article

BET proteins are required for transcriptional activation of the senescent beta cell secretome in Type 1 Diabetes

2019-08-15

Abstract excerpt

<h4>OBJECTIVE</h4> Type 1 Diabetes (T1D) results from progressive loss of pancreatic beta cells due to autoimmune destruction. We recently reported that during the natural history of T1D in humans and the female nonobese diabetic (NOD) mouse model, beta cells acquire a senescence-associated secretory phenotype (SASP) that is a major driver of disease onset and progression, but the mechanisms that activate SASP in...

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Literature Corpus work: f6a1c1d1-40ef-5c1a-828a-9adcf0fd99f1
DOI: 10.1101/736231

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