Article

DNA damage models phenotypes of β cell senescence in Type 1 Diabetes

2021-06-07

Abstract excerpt

<h4>Objective</h4> Type 1 Diabetes (T1D) is characterized by progressive loss of insulin-producing pancreatic β cells as a result of autoimmune destruction. In addition to β cell death, recent work has shown that subpopulations of β cells acquire dysfunction during T1D. We previously reported that some β cells adopt a senescent fate involving a DNA damage response (DDR) during the pathogenesis of T1D, however, th...

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Literature Corpus work: 140bf32e-8354-5751-9ca5-9926ae72c533
DOI: 10.1101/2021.06.07.447428

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