Article

Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis

2020-03-06

Abstract excerpt

<h4>Summary</h4> Proliferative quiescence in β-cells is required to maintain functional competence. While this presents a significant hurdle in regenerative therapy for diabetes, the molecular underpinnings of this reciprocal relationship remain unclear. Here, we demonstrate that TEAD1, the transcription effector of the mammalian-Hippo pathway, drives developmental stage-specific β-cell proliferative capacity in...

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Literature Corpus work: 0a46130e-0014-59e6-ad43-74c5b2c9b521
DOI: 10.1101/2020.03.05.979450

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