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Article

BET bromodomain inhibition suppresses TH17-mediated pathology

7 Oct 2013

Abstract excerpt

Interleukin (IL) 17-producing T helper (T(H)17) cells have been selected through evolution for their ability to control fungal and bacterial infections. It is also firmly established that their aberrant generation and activation results in autoimmune conditions. Using a characterized potent and selective small molecule inhibitor, we show that the bromodomain and extra-terminal domain (BET) family of chromatin...

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PMID: 24101376
DOI: 10.1084/jem.20130376

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