BET family members Bdf1/2 modulate global transcription initiation and elongation in <i>Saccharomyces cerevisiae</i>

Abstract excerpt

Human bromodomain-containing BET family members are promising targets for therapy of cancer and immunoinflammatory diseases, but their mechanisms of action and functional redundancies are poorly understood. Bdf1/2, yeast homologues of the human BET factors, were previously proposed to target transcription factor TFIID to acetylated histone H4, analogous to bromodomains that are present within the largest subunit o...

Topics

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• Adaptive Immunity
• CCCTC-Binding Factor
• Chromosomal Proteins, Non-Histone
• Cohesins
• Interferon Regulatory Factors
• Protein Degradation and Inhibitors
• RNA Polymerase II
• STAT3 Transcription Factor

Identifiers and source

Literature Corpus work

47a3a3f0-fce4-5d1b-9637-3e4345bec060

DOI

10.1101/2021.04.20.440672