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DNA damage to β cells in culture recapitulates features of senescent β cells that accumulate in type 1 diabetes

2 Jun 2022

Abstract excerpt

OBJECTIVE: Type 1 Diabetes (T1D) is characterized by progressive loss of insulin-producing pancreatic β cells as a result of autoimmune destruction. In addition to β cell death, recent work has shown that subpopulations of β cells acquire dysfunction during T1D. We previously reported that β cells undergoing a DNA damage response (DDR) and senescence accumulate during the pathogenesis of T1D. However, the...

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PMID: 35660116
DOI: 10.1016/j.molmet.2022.101524

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